Heartworm Prevention: Sentinel Spectrum should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure. If it is suspected that any of the doses have been lost, redosing is recommended. Care should be taken that the dog consumes the complete dose, and treated animals should be observed a few minutes after administration to ensure that no part of the dose is lost or rejected. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes. Sentinel Spectrum should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg) lufenuron, and 2.28 mg/lb (5 mg/kg) praziquantel. Keep this and all drugs out of the reach of children.
Studies have been performed with milbemycin oxime and lufenuron alone. The safety of this medication has not been evaluated in dogs used for breeding or in lactating females. Do not use in dogs or puppies less than two pounds of body weight. Do not use in puppies less than six weeks of age. These reactions are presumably caused by release of protein from dead or dying microfilariae. Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. This medication is not effective against adult D. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Prior to administration of Sentinel Spectrum, dogs should be tested for existing heartworm infections. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.
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